Txhim Kho Kev Saib Xyuas Tus Neeg Mob Nrog Kev Kho Kom Zoo Dua Los Ntawm AI Hauv Kev Thaij Duab PET

Ib txoj kev tshawb fawb tshiab hu ua "Siv Pix-2-Pix GAN rau Kev Kho Kom Zoo Dua Hauv Lub Cev PSMA PET/CT" tau luam tawm tsis ntev los no hauv Ntawv 15 ntawm Oncotarget thaum Lub Tsib Hlis 7, 2024.

Qhov kev raug hluav taws xob los ntawm kev tshawb fawb PET/CT ua ntu zus hauv kev saib xyuas cov neeg mob qog noj ntshav yog qhov txhawj xeeb. Hauv kev tshawb nrhiav tsis ntev los no, ib pab pawg kws tshawb fawb suav nrog Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, thiab Stephanie A. Harmon los ntawm National Cancer Institute ntawm National Institutes of Health tau qhia txog lub cuab yeej txawj ntse (AI). Lub cuab yeej no lub hom phiaj yog los tsim cov duab PET (AC-PET) uas kho tau los ntawm cov duab PET (NAC-PET) uas tsis kho tau, tej zaum yuav txo qhov xav tau rau kev ntsuas CT tsawg.

Cov duab PET uas tsim los ntawm AI muaj peev xwm kho tau kom txo qhov xav tau kev kho kom zoo ntawm CT scans thaum tseem khaws cov cim qhia kom muaj nuj nqis thiab cov duab zoo rau cov neeg mob qog nqaij hlav prostate.

Cov Txheej Txheem: Ib qho kev kawm tob tob raws li 2D Pix-2-Pix generative adversarial network (GAN) architecture tau tsim los ntawm kev sib koom ua ke ntawm cov duab AC-PET thiab NAC-PET. Kev tshawb fawb 18F-DCFPyL PSMA (Prostate-specific membrane antigen) PET-CT ntawm 302 tus neeg mob uas muaj mob qog nqaij hlav prostate tau muab faib ua pawg kev cob qhia, kev lees paub, thiab kev sim (n 183, 60, thiab 59, feem). Tus qauv tau kawm siv ob txoj kev tswj hwm: Standard Uptake Value (SUV) raws li thiab SUV-NYUL raws li. Kev ua tau zoo ntawm kev luam theej duab kab rov tav tau soj ntsuam siv normalized mean square error (NMSE), mean absolute error (MAE), structural similarity index (SSIM) thiab peak signal-to-noise ratio (PSNR). Tus kws kho mob nuclear tau ua qhov kev tshuaj xyuas qib lesion ntawm thaj chaw uas xav tau. Cov cim SUV tau soj ntsuam siv intra-group correlation coefficient (ICC), repeatability coefficient (RC), thiab linear mixed effects models.

Cov txiaj ntsig：Hauv pawg neeg sim ywj pheej, qhov nruab nrab NMSE, MAE, SSIM, thiab PSNR yog 13.26%, 3.59%, 0.891, thiab 26.82, raws li. ICC rau SUVmax thiab SUVmean yog 0.88 thiab 0.89, qhia txog kev sib raug zoo ntawm cov cim duab thawj thiab AI-tsim. Cov yam xws li qhov chaw mob, qhov ceev (Hounsfield units), thiab kev nqus ntawm qhov mob tau pom tias cuam tshuam rau qhov yuam kev sib piv hauv SUV metrics tsim (txhua p < 0.05).

"AC-PET uas tsim los ntawm Pix-2-Pix GAN qauv qhia txog SUV metrics uas sib phim nrog cov duab qub. AI-generated PET cov duab qhia txog kev muaj peev xwm kho mob zoo rau kev txo qhov xav tau ntawm CT scans rau kev kho qhov tsis zoo thaum tswj cov cim ntsuas thiab cov duab zoo."

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Raws li peb txhua tus paub, kev txhim kho ntawm kev lag luam duab kho mob yog qhov tsis sib cais los ntawm kev txhim kho ntawm cov khoom siv kho mob - cov tshuaj txhaj tshuaj sib piv thiab lawv cov khoom siv txhawb nqa - uas siv dav hauv daim teb no. Hauv Suav teb, uas nto moo rau nws txoj kev lag luam tsim khoom, muaj ntau lub tuam txhab tsim khoom nto moo hauv tsev thiab txawv teb chaws rau kev tsim cov khoom siv duab kho mob, suav nrogLnkMedTxij li thaum nws tau tsim los, LnkMed tau tsom mus rau thaj chaw ntawm cov tshuaj txhaj tshuaj siab. Pab pawg kws tsim khoom ntawm LnkMed yog coj los ntawm Ph.D. uas muaj ntau tshaj kaum xyoo ntawm kev paub dhau los thiab koom nrog kev tshawb fawb thiab kev txhim kho. Nyob rau hauv nws txoj kev coj, lubCT ib lub taub hau injector,CT ob lub taub hau injector,MRI contrast agent injector, thiabAngiography high pressure contrast agent injectortau tsim los nrog cov yam ntxwv no: lub cev muaj zog thiab me me, qhov yooj yim thiab ntse ua haujlwm interface, cov haujlwm tiav, kev nyab xeeb siab, thiab tsim qauv ruaj khov. Peb kuj tuaj yeem muab cov koob txhaj tshuaj thiab lub raj uas sib xws nrog cov npe nrov ntawm CT, MRI, DSA injectors Nrog lawv tus cwj pwm siab dawb paug thiab lub zog ua haujlwm, txhua tus neeg ua haujlwm ntawm LnkMed thov caw koj tuaj thiab tshawb nrhiav ntau lub khw ua ke.