Kev kuaj mob feem ntau pab kom kuaj tau zoo thiab kho mob qog noj ntshav. Tshwj xeeb, magnetic resonance imaging (MRI) yog siv dav vim nws qhov kev daws teeb meem siab, tshwj xeeb tshaj yog nrog cov neeg ua haujlwm sib txawv.
Ib txoj kev tshawb fawb tshiab luam tawm nyob rau hauv phau ntawv Journal Advanced Science qhia txog tus kheej-folding nanoscale qhov sib txawv tus neeg sawv cev tshiab uas yuav pab pom cov qog kom nthuav dav ntau dua ntawm MRI.
Qhov sib txawv yog dab tsixov xwm?
Contrast media (tseem hu ua contrast media) yog cov tshuaj uas tau txhaj (los yog muab) rau hauv tib neeg cov ntaub so ntswg los yog lub cev los txhim kho cov duab saib. Cov kev npaj no yog denser lossis qis dua cov ntaub so ntswg ib puag ncig, tsim qhov sib piv uas yog siv los tso saib cov duab nrog qee cov khoom siv. Piv txwv li, kev npaj iodine, barium sulfate, thiab lwm yam yog feem ntau siv rau kev soj ntsuam X-ray. Nws yog txhaj rau hauv tus neeg mob cov hlab ntsha los ntawm lub siab sib txawv syringe.
Ntawm nanoscale, molecules tseem nyob hauv cov ntshav rau lub sijhawm ntev thiab tuaj yeem nkag mus rau cov qog nqaij hlav yam tsis muaj kev cuam tshuam cov qog tshwj xeeb tiv thaiv kab mob. Ob peb molecular complexes raws li nanomolecules tau kawm raws li muaj peev xwm nqa tau CA rau hauv cov qog.
Cov nanoscale contrast agents (NCAs) yuav tsum tau muab faib kom zoo ntawm cov ntshav thiab cov ntaub so ntswg ntawm kev txaus siab kom txo cov suab nrov tom qab thiab ua tiav qhov siab tshaj plaws-rau- suab nrov piv (S / N). Nyob rau hauv siab concentrations, NCA nyob rau hauv cov hlab ntsha nyob rau lub sij hawm ntev ntawm lub sij hawm, yog li ua rau muaj kev pheej hmoo ntawm nws kim heev fibrosis vim tso tawm ntawm gadolinium ions los ntawm complex.
Hmoov tsis zoo, feem ntau NCAs siv tam sim no muaj cov rooj sib txoos ntawm ntau hom molecules. Hauv qab ib qho chaw pib, cov micelles lossis cov sib sau ua ke yuav sib cais, thiab qhov tshwm sim ntawm qhov kev tshwm sim no tsis meej.
Qhov no txhawb kev tshawb fawb rau hauv tus kheej-folding nanoscale macromolecules uas tsis muaj qhov tseem ceeb ntawm kev sib cais. Cov no muaj xws li ib tug fatty core thiab ib tug soluble txheej txheej uas kuj txwv lub zog ntawm soluble units nyob rau hauv lub contact nto. Qhov no tuaj yeem cuam tshuam qhov kev so ntawm molecular thiab lwm yam haujlwm uas tuaj yeem siv los txhim kho kev xa tshuaj thiab cov khoom tshwj xeeb hauv vivo.
Contrast media feem ntau yog txhaj rau hauv tus neeg mob lub cev los ntawm lub siab sib txawv injector.LnkMed, cov chaw tsim khoom lag luam tsom mus rau kev tshawb fawb thiab kev txhim kho ntawm tus neeg sawv cev zoo sib xws thiab txhawb nqa cov khoom siv, tau muag nwsCT, MRI, thiabDSAtxhaj tshuaj nyob hauv tsev thiab txawv teb chaws thiab tau lees paub los ntawm kev ua lag luam hauv ntau lub teb chaws. Peb lub Hoobkas tuaj yeem muab txhua yam kev txhawb nqakhoom sivtam sim no nrov hauv tsev kho mob. Peb lub Hoobkas muaj cov txheej txheem tshuaj xyuas zoo rau kev tsim khoom, xa khoom sai, thiab kev pabcuam zoo tom qab muag. Txhua tus neeg ua haujlwm ntawmLnkMedvam tias yuav koom nrog ntau dua hauv kev lag luam angiography yav tom ntej, txuas ntxiv tsim cov khoom zoo rau cov neeg siv khoom, thiab muab kev saib xyuas rau cov neeg mob.
Qhov kev tshawb fawb qhia li cas?
Ib lub tswv yim tshiab tau qhia hauv NCA uas txhim kho lub sijhawm ntev ntawm kev so ntawm cov protons, tso cai rau nws tsim cov duab zoo dua ntawm cov khoom qis dua ntawm gadolinium complexes. Kev thauj khoom qis dua txo qhov kev pheej hmoo ntawm kev tsis zoo vim tias cov koob tshuaj CA tsawg tsawg.
Vim yog tus kheej-folding cov cuab yeej, qhov tshwm sim SMDC muaj cov tub ntxhais ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom ntom. Qhov no ua rau kom muaj kev so kom txaus thaum lub zog sab hauv thiab ntu ib ncig ntawm SMDC-Gd interface yuav raug txwv.
Qhov NCA no tuaj yeem sib sau ua ke hauv cov qog, ua rau nws tuaj yeem siv Gd neutron capture therapy los kho cov qog ntau qhov tshwj xeeb thiab ua tau zoo. Txog rau hnub tim, qhov no tsis tau ua tiav kev kho mob vim tsis muaj kev xaiv kom xa 157Gd rau cov qog thiab tswj lawv ntawm qhov tsim nyog. Qhov yuav tsum tau txhaj tshuaj ntau yog cuam tshuam nrog cov teebmeem tsis zoo thiab cov txiaj ntsig tsis zoo vim tias qhov loj ntawm gadolinium nyob ib puag ncig cov qog tiv thaiv nws los ntawm kev raug neutron.
Lub nanoscale txhawb kev xaiv tsub zuj zuj ntawm cov tshuaj kho mob thiab pom kev faib tshuaj hauv cov qog. Cov molecules me tuaj yeem tawm ntawm capillaries, ua rau muaj kev ua haujlwm antitumor ntau dua.
“Muab hais tias txoj kab uas hla ntawm SMDC yog tsawg dua 10 nm, peb qhov kev tshawb pom muaj feem yuav tshwm sim los ntawm qhov tob tob ntawm SMDC mus rau hauv cov qog, pab kom dim ntawm qhov thaiv ntawm thermal neutrons thiab ua kom muaj txiaj ntsig zoo ntawm cov hluav taws xob thiab gamma rays tom qab thermal neutron raug.“
Dab tsi yog qhov cuam tshuam?
"Tuaj yeem txhawb nqa kev txhim kho ntawm SMDCs zoo rau kev kuaj mob qog noj ntshav zoo dua, txawm tias yuav tsum tau txhaj tshuaj MRI ntau."
"Peb qhov kev tshawb pom tau qhia txog lub peev xwm los kho NCAJ los ntawm tus kheej-folding molecular tsim thiab kos ib qho kev nce qib hauv kev siv NCA hauv kev kuaj mob qog noj ntshav thiab kho mob."
Post lub sij hawm: Dec-08-2023
